Preclinical pharmacological study on 125I-IPPA

首页> 外文期刊>核技术（英文版） >Preclinical pharmacological study on 125I-IPPA

【24h】

Preclinical pharmacological study on 125I-IPPA

机译：125I-IPPA的临床前药理研究

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

页面导航

摘要
著录项
相关主题

摘要

Myocardial uptake of 125I-IPPA in rats showed a peak of 4.4% of injected dose per gram.The half elimination time of myocardium was 3.8min and the maximaluptake of thyroid is only 0.005%ID/organ at 120min.The initial halftime of 2.7min in rabbits was obtained from the elimination curve ofradioactivity in blood.In vitro binding test for 125I-IPPA to HSAshowed rather constant level of activation during two hours.The second peak of extraction was observed in major organs ofrats, in rabbits' elimination of radioactivity and in bindingtest for 125I-IPPA to albumin in vivo.Toxicity trial was up tostandard.The tolerance of a mouse to IPPA was 560 times as highas that of a person to IPPA.It demonstrated that 125I-IPPA couldbe quickly extracted by myocardium, and its catabolites were excretedin the urine with almost no iodine loss.All the results were found toagree with the expectations based on the principal metabolic path ofphenyl fatty acid.

机译：大鼠心肌摄取125 I-IPPA的峰值显示为每克注射剂量的4.4％。心肌的半衰期为3.8分钟，甲状腺在120分钟时的最大摄取仅为0.005％ID /器官，初始半衰期为2.7分钟从125 I-IPPA对HSA的体外结合试验显示，在两个小时内激活水平相当稳定。在大鼠的主要器官中观察到了第二个提取峰，这是兔体内放射性消除的结果。体内125I-IPPA与白蛋白的结合试验，毒性试验达到标准，小鼠对IPPA的耐受性是人对IPPA的560倍，证明了125I-IPPA可以被心肌及其器官快速提取。尿中排出的分解代谢物几乎没有碘流失。根据苯脂肪酸的主要代谢途径，所有结果均符合预期。

著录项

来源
《核技术（英文版）》 |1999年第1期|8-10|共3页
作者

展开▼
作者单位

State Key Laboratory of Nuclear Medicine,Jiangsu Institute of Nuclear Medicine, Wuxi 214063;

State Key Laboratory of Nuclear Medicine,Jiangsu Institute of Nuclear Medicine, Wuxi 214063;

State Key Laboratory of Nuclear Medicine,Jiangsu Institute of Nuclear Medicine, Wuxi 214063;

State Key Laboratory of Nuclear Medicine,Jiangsu Institute of Nuclear Medicine, Wuxi 214063;

State Key Laboratory of Nuclear Medicine,Jiangsu Institute of Nuclear Medicine, Wuxi 214063;

State Key Laboratory of Nuclear Medicine,Jiangsu Institute of Nuclear Medicine, Wuxi 214063;

展开▼
收录信息中国科学引文数据库(CSCD);
原文格式 PDF
正文语种 chi
中图分类物理学;
关键词
125I-IPPA, Radioiodinated fattyacid, Animal study;

机译：125I-IPPA;放射性碘脂肪酸;动物研究;

Preclinical pharmacological study on 125I-IPPA

摘要

著录项

相关主题

期刊订阅