Preparation of Hydroxypropyl Methylcellulose Acetate Succinate with a Narrow Molecular Weight Dispersion

Liangliang Zhang; Shiyu Fu

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Preparation of Hydroxypropyl Methylcellulose Acetate Succinate with a Narrow Molecular Weight Dispersion

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Hydroxypropyl methylcellulose acetate succinate(HPMCAS)was successfully synthesized from the reaction of hydroxypropyl methylcellulose with succinic anhydride and acetic anhydride in an acetone/pyridine system.Products with different contents of succinyl groups and acetyl groups were prepared by varying the reaction conditions.In the acetone/pyridine system,equipment corrosion does not occur,the product is easy to wash,and the solvent can be recycled.By varying the concentration of the esterifying agents,products with different ratios of acidic groups can be obtained.Under the optimum conditions,the obtained products had an average molecular weight between 5.39×104 and 5.41×104,a number average molecular weight from 4.97×104 to 5.13×104,and a polydispersity index from 1.05 to 1.08.The products dissolved well in acetone and methanol,and formed films on a mold.The films had good pH-sensitivity,tensile strength,and thermal stability.The formed films could dissolve in solutions with a pH value ranging from 5.4 to 6.4,and are therefore suitable for use as an enteric coating for pharmaceutical dosage forms.

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《造纸与生物质材料：英文版》 |2020年第4期|P.36-43|共8页
作者
Liangliang Zhang; Shiyu Fu;
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作者单位

State Kay Laboratory of Pulp and Paper Engineering School of Light Science and Engineering South China University of Technology Guangzhou Guangdong Province 510640 China;

State Kay Laboratory of Pulp and Paper Engineering School of Light Science and Engineering South China University of Technology Guangzhou Guangdong Province 510640 China;

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原文格式 PDF
正文语种 chi
中图分类有机化学;
关键词
cellulose derivatives; HPMCAS; narrow molecular weight distribution;

机译：纤维素衍生物;HPMCA;窄分子量分布;

Preparation of Hydroxypropyl Methylcellulose Acetate Succinate with a Narrow Molecular Weight Dispersion

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