Preparation of Chitosan-based Microspheres for Rapid Hemostasis

Yan Fang; Peiyuan Li; Weikang Zhou

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Preparation of Chitosan-based Microspheres for Rapid Hemostasis

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Rapid control of heavy hemorrhaging is critical to save the life of injured individuals.Herein,we developed a novel hemostat employing chitosan-based microspheres,which was prepared by sequential microemulsion of chitosan solution,sol-gel phase transition,and surface modification by 3,4-dihydroxyhydrocinnamic acid(HCA).HCA-modified chitosan microspheres(CSMS-HCA)displayed a porous structure,with a high specific surface area(~211.3 m^(2)/g),accelerating their rapid absorption of blood and concentrating red cells and platelets.The CSMS-HCA exhibited much better in vitro and in vivo hemostatic efficacy than porous chitosan microspheres did.Such a rapid hemostat in the form of microspheres is highly effective in treating deep and irregular wounds,owing to easy accessibility to injured sites.

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《造纸与生物质材料：英文版》 |2021年第1期|P.41-49|共9页
作者
Yan Fang; Peiyuan Li; Weikang Zhou;
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作者单位

Fujian Provincial Key Laboratory of Polymer Materials College of Chemistry and Materials Science Fujian Normal University Fuzhou Fujian Province 350007 China;

Fujian Provincial Key Laboratory of Polymer Materials College of Chemistry and Materials Science Fujian Normal University Fuzhou Fujian Province 350007 China;

Fujian Provincial Key Laboratory of Polymer Materials College of Chemistry and Materials Science Fujian Normal University Fuzhou Fujian Province 350007 China;

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原文格式 PDF
正文语种 chi
中图分类高分子化学（高聚物）;
关键词
chitosan; microspheres; hemostasis; wet-tissue adhesion;

机译：壳聚糖;微球;止血;湿组织粘附;

Preparation of Chitosan-based Microspheres for Rapid Hemostasis

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