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首页> 中文期刊> 《亚洲药物制剂科学(英文)》 >Preparation of glutinous rice starch/polyvinyl alcohol copolymer electrospun fibers for using as a drug delivery carrier

Preparation of glutinous rice starch/polyvinyl alcohol copolymer electrospun fibers for using as a drug delivery carrier

         
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cqvip:Glutinous rice starch(GRS) is commonly produced in the Northeast of Thailand. GRS is a biopolymer which is widely used in the food industry but not yet commonly applied within the pharmaceutical industry as an alternative resource. GRS exhibits a branch chain structure which is not feasible to fabricate as nanofiber. Therefore, combining GRS with polyvinyl alcohol(PVA) in hybrid form can be a potential platform to produce GRS-PVA nanofibers.Smooth nanofibers of 2%(w/v) GRS combined with 8%(w/v) PVA were fabricated by an electrospinning process. A scanning electron microscope(SEM) revealed an average diameter size of the GRS-PVA nanofibers equal to 191 ± 25 nm. A highly water soluble model drug,Chlorpheniramine maleate(CPM), was incorporated into the GRS-PVA electrospun fibers to prove a drug delivery carrier concept and drug release control of the nanofibers. The GRSPVA nanofibers exhibited a biphasic CPM release in which approximately 60% of the drug immediately released in 10 min, and it reached 90% drug release in 120 min. This study demonstrated a potential application of GRS combining with PVA as an oral drug delivery carrier.Therefore, it can be a promised step that expands the application GRS in pharmaceuticals and related areas.

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