目的：探讨Ⅲ期卵巢上皮性癌复发的危险因素。方法将Ⅲ期卵巢上皮性癌患者80例，分为复发组26例，未复发组54例。观察患者的临床病理参数以及治疗等因素。结果复发组在腹水肿瘤细胞学、残留病灶、淋巴结清除、术后2个月CA125水平、化疗疗程、MMP-2表达方面与未复发组比较差异显著（P＜0．05）；多因素 Logistic 回归分析显示腹水肿瘤细胞学呈阳性、残留病灶≥2 cm、淋巴结清除、术后2个月CA125≥35 U/L、MMP-2表达阳性是影响复发的独立危险因素。结论Ⅲ期卵巢上皮性癌复发的预测因素有术后CA125、MMP-2水平、残留病灶大小、淋巴结是否清除、腹水肿瘤细胞学性质。%Objective To investigate the risk factors of stageⅢrecurrent ovarian epithelial cancer .Methods 80 stageⅢovarian epithelial cancer patients were divided into the recurrent group (n=26)and the non-recurrent group (n=54).Clini-cal parameters ,histological parameters , chemotherapy , and other factors were observed .Results There were significant differ-ences in ascites cytology,residual lesions,lymph node dissection,CA125 level 2 months after operation,chemotherapy courses, MMP-2 expression between the 2 groups(P<0.05);Multivariate analysis showed that positive expression of ascites cytology ,re-sidual lesions≥2 cm,lymph node dissection,CA125≥35 U/L 2 months after operation,and positive expression of MMP-2 were independent risk factors affecting recurrence in patients with ovarian epithelial cancer .Conclusion The important prognostic fac-tors of stage Ⅲrecurrent ovarian epithelial cancer are CA 125 and MMP-2 level after operation,residual tumor size,lymph node resection status and cytology of ascites tumors .
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