Objective:To observe the clinical effect of metfomin intervention in the treatment of patients with type 2 diabe-tes mellitus and cerebral infarction. Methods:All 186 hospitalized cases with type 2 diabetes mellitus and cerebral infarction from July in 2013 to December in 2015 randomly divided into metfomin intervention group and control group. The patients of control group were given diet,exercise and insulin,aspirin,improve the brain blood flow,intervention group on the basis of con-trol group therapy combined with metformin. 24 weeks were determined before and after treatment in patients with the change of weight(BW),body mass index(BMI),fasting blood - glucose(FBG),2 - hour postprandial blood glucose(2hPBG),hemoglo-bin A1c(HbA1c),systolic pressure(SBP)/ diastolic pressure(DBP),triacylglycerol(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL - C),high density lipoprotein cholesterol(HDL - C),homocysteine(HCY),high - sensitivity C- reactive protein(hs - CRP),inteima - media thicknes(IMT). Results:In the two groups after treatment in patients with re-duced BW,BMI,FBG,2hPBG,HbA1c,SBP/ DBP,TC,TG,LDL - C,hs - CRP,IMT,intervention group therpy effect is better than the control group. In the two groups after treatment in patients with reduced Hcy,two groups have no difference. Conclu-sion:A curative effect on the patients with type 2 diabetes mellitus and cerebral infarction.%目的：观察二甲双胍干预治疗脑梗死合并2型糖尿病患者的疗效。方法：选取2013年7月—2015年12月收治的脑梗死合并2型糖尿病患者186例，随机分为干预组和对照组，对照组给予控制饮食、适量锻炼、胰岛素注射、阿司匹林、阿托伐他汀钙及计对症支持治疗。干预组在对照组的基础上加用二甲双胍干预治疗。治疗前及治疗后24周分别测定患者体重（ BW）、身体质量指数（ BMI）、空腹血糖（ FBG）、餐后两小时血糖（2 hPBG）、糖化血红蛋白（HbA1c）、收缩压/舒张压（SBP/ DBP）、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL - C）、高密度脂蛋白胆固醇（HDL - C）、同型半胱氨酸（HCY）、高敏 C 反应蛋白（hs - CRP）、颈动脉内膜中层厚度（IMT）的变化。结果：治疗后两组的 BW，BMI，FBG，2 hPBG，HbA1c，SBP/ DBP，TC，TG，LDL - C，hs - CRP，IMT 均明显降低，HDL - C 明显升高，干预组治疗效果优于对照组，差异有统计学意义（P ﹤0.05）。治疗后两组 HCY 较治疗前明显下降（P ﹤0.05），但两组之间比较差异无统计学意义（P ﹥0.05）。结论：二甲双胍干预治疗脑梗死合并2型糖尿病患者，有明显的协同降低 BM，BMI，FBG，2 hPBG，HbA1c，SBP/ DBP，hs - CRP 的作用，同时又能降低 TC，TG，LDL - C 和升高 HDL - C，对脑梗死合并2型糖尿病患者起到了综合治疗的效果。
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