Reduced cell death by inosine pretreatment after photochemically induced cerebral ischemia in adult rats

Zhongliang Wu; Fei Liu; Yazhou Wang; Xiying Jiao; Ming Shi; Qingbo Zhao; Gong Ju; Siwei You

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Reduced cell death by inosine pretreatment after photochemically induced cerebral ischemia in adult rats

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Protective effect of inosine against cell death after photochemically induced focal cerebral ischemia was investigated in adult rats.Intraperitoneal injection of inosine was started 24 h before operation and continued till the animals were sacrificed.The TUNEL method and Nissl staining were used to identify apoptosis and necrosis,respectively.TUNEL-positive cells were located in the transitional zone between the necrotic core and normal cortex.The mean maximum area of the necrotic cores and mean number of TUNEL-positive cells 24 h after operation were reduced significantly in the inosine-treated rats when compared with those in the saline-treated control animals.We suggest that inosine can significantly reduce both necrosis and apoptosis following cerebral ischemia induced by photothrombosis in adult rats.

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《自然科学进展（英文版）》 |2008年第12期|1513-1518|共6页
作者
Zhongliang Wu; Fei Liu; Yazhou Wang; Xiying Jiao; Ming Shi; Qingbo Zhao; Gong Ju; Siwei You;
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Institute of Neurosciences,The Fourth Military Medical University,17 Changlexi Road, Xi'an 710032, China;

Institute of Neurosciences,The Fourth Military Medical University,17 Changlexi Road, Xi'an 710032, China;

Institute of Neurosciences,The Fourth Military Medical University,17 Changlexi Road, Xi'an 710032, China;

Institute of Neurosciences,The Fourth Military Medical University,17 Changlexi Road, Xi'an 710032, China;

Institute of Neurosciences,The Fourth Military Medical University,17 Changlexi Road, Xi'an 710032, China;

Department of Biostatistics, The Fourth Military Medical University, 17 Changlexi Road, Xi'an 710032,China;

Institute of Neurosciences,The Fourth Military Medical University,17 Changlexi Road, Xi'an 710032, China;

Institute of Neurosciences,The Fourth Military Medical University,17 Changlexi Road, Xi'an 710032, China;

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Reduced cell death by inosine pretreatment after photochemically induced cerebral ischemia in adult rats

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