Selenium-dependent glutathione peroxidases——A highlight of the role of phospholipid hydroperoxide glutathione peroxidase in protection against oxidative damage

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Selenium-dependent glutathione peroxidases——A highlight of the role of phospholipid hydroperoxide glutathione peroxidase in protection against oxidative damage

机译：硒依赖性谷胱甘肽过氧化物酶-磷脂氢过氧化物谷胱甘肽过氧化物酶在抗氧化损伤中的作用的亮点

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Since the discovery that selenium is an integral component of the active site of the mammalian glu-tathione peroxidase, four members of the glutathione peroxidase family have been characterised: classical cellular glu-tathione peroxidase, gastrointestinal glutathione peroxidase; plasma glutathione peroxidase and phospholipid hydroperox-ide glutathione peroxidase (PHGPx). They are products of different genes and have different specificities on hydrogenperoxide and lipid hydroperoxides, the latter are generated by free radicals and can damage cell membranes and disruptcellular functions. Interestingly, PHGPx is not only active on phospholipid hydroperoxide, but also active on thyminehydroperoxide (a model compound for DNA damage) and protein hydroperoxides. This review highlights the role ofPHGPx in protection against peroxidative damage of lipids, protein and DNA.

机译：自从发现硒是哺乳动物谷胱甘肽过氧化物酶活性位点的组成部分以来，已经表征了谷胱甘肽过氧化物酶家族的四个成员：经典的细胞谷胱甘肽过氧化物酶，胃肠道谷胱甘肽过氧化物酶;谷胱甘肽过氧化物酶。血浆谷胱甘肽过氧化物酶和磷脂氢过氧化物-谷胱甘肽过氧化物酶（PHGPx）。它们是不同基因的产物，对过氧化氢和脂质氢过氧化物具有不同的特异性，后者是由自由基产生的，可破坏细胞膜并破坏细胞功能。有趣的是，PHGPx不仅对磷脂氢过氧化物具有活性，而且对胸腺嘧啶氢过氧化物（DNA损伤的模型化合物）和蛋白质氢过氧化物也具有活性。这篇综述强调了PHGPx在防止脂质，蛋白质和DNA的过氧化损伤中的作用。

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《自然科学进展（英文版）》 |2000年第5期|321-330|共10页
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Diet,Health and Consumer Sciences Division,Institute of Food Research,Norwich Research Park,Norwich,NR4 7UA,UK;

Department of Nutrition and Food Hygiene,Harbin Medical University,Harbin 150001,China;

Diet,Health and Consumer Sciences Division,Institute of Food Research,Norwich Research Park,Norwich,NR4 7UA,UK;

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正文语种 chi
中图分类化学;
关键词
selenium; selenoprotein; phospholipid hydroperoxide; glutathione peroxidase; oxidative damage;

机译：硒;硒蛋白;磷脂氢过氧化物;谷胱甘肽过氧化物酶;氧化损伤;

Selenium-dependent glutathione peroxidases——A highlight of the role of phospholipid hydroperoxide glutathione peroxidase in protection against oxidative damage

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