A novel electrochemical sensor based on（3-aminopropyl）triethoxysilane（APTES） functionalized Si02 supported Au nanoparticles and Nafion（Nf） as the protective membrane was fabricated for the electrochemical determination of H2O2 in contact lens-cleaning solution.The modification steps of glassy carbon working electrode（GCE） were evaluated by electrochemical impedance spectroscopy（EIS） and cyclic voltammetry（CV）.The amperometric results showed that Nf/Au@Si02-APTES/GCE sensor can be used to determine H2O2 in contact lens solutions with the linear ranges of 14-180 μM and 0.18-7.15 mM,excellent sensitivities of 2514.6 and894.2 μA mM cm-2,and a low limit of detection（LOD） of 4.25 μM depending upon signal-to-noise ratio of 3.Nf/Au@Si02-APTES/GCE exhibited excellent repeatability with relative standard deviation（RDS） of 2.66% and acceptable reproducibility with RSD of 3.35%.The sensor displayed reasonable selectivity in the presence of uric acid,dopamine,ascorbic acid,glucose,mannose,glycine,fructose,histidine,and arginine with RSD less than2.5%.The fabricated Nf/Au@Si02-APTES/GCE sensor has been successfully applied to detect H2O2 in contact lens cleaning solutions.
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