Radiobiological response of human hepatoma and normal liver cells exposed to carbon ions generated by Heavy Ion Research Facility in Lanzhou

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Radiobiological response of human hepatoma and normal liver cells exposed to carbon ions generated by Heavy Ion Research Facility in Lanzhou

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Human hepatoma and normal liver cells were irradiated with 12C6+ ion beams (LET = 96.05 keV/μm) and γ-rays at Heavy Ion Research Facility in Lanzhou (HIRFL). The chromatid breaks and break types were detected using the premature chromosome condensation technique. Our experimental results showed that chromatid breaks seem to have a good relation with 12C6+ absorbed dose and 12C6+ are more effective to induce chromatid breaks as compared to the γ-rays. For 12C6+ ion irradiation the major break was isochromatid break, while chromatid breaks were dominant for γ-ray irradiation. We also observed that the Relative Biology Effectiveness (RBE) of 12C6+ ion is about 2.5 times higher than that of γ-rays.

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《中国科学:物理学力学天文学（英文版）》 |2006年第1期|72-76|共5页
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Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China;

Life Science School of North West Normal University Lanzhou 730070 China;

Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China;

Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China;

Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China;

Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China;

Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China;

Life Science School of Lanzhou University Lanzhou 730000 China;

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原文格式 PDF
正文语种 chi
中图分类化学;
关键词
biological response; tumor cell; normal cell; heavy ion HIRFL;

机译：生物反应;肿瘤细胞;正常的细胞;重离子hirfl;

Radiobiological response of human hepatoma and normal liver cells exposed to carbon ions generated by Heavy Ion Research Facility in Lanzhou

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