In the paper,we reported the development of a simple condensation and oxidation from starting compound salicylaldehyde and 2-hydroxylaniline to give 2-(2′-hydroxyphenyl )benzoxazole (HBO)under solvent-free condition.We used BTI as oxidant in ring-closing step and investigated opti-mized condition under 40 ℃,50 minutes to give target compound HBO in good yield.Target compound was confirmed by 1 H NMR,13 C NMR and LC/MS.%水杨醛和邻羟基苯胺为原料通过缩合和氧化两步反应,无溶剂条件下合成得到HBO,通过实验优化反应条件,最佳反应条件为以BTI为氧化剂,40℃,反应50 min得到目标化合物HBO,反应收率达84%,目标化合物通过核磁和质谱得到确证.
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