研究了一种可快速拆分氧氟沙星的方法;该方法采用分子印迹技术,用二氧化硅包裹的Fe3 O4磁性纳米颗粒为载体,再用手性试剂N-正辛基-D-葡萄糖胺作为单体,以氧氟沙星作为模板分子制备磁性表面分子印迹聚合物.该手性聚合物可与右旋氧氟沙星结合,最终分离出左旋氧氟沙星.最后利用外加磁场及透射电子显微镜对于所制备的氧氟沙星磁性分子印迹聚合物的性状进行检测;并对分离得到的左旋氧氟沙星进行旋光度的检测.%A method of quickly resolving ofloxacin using molecular imprinting technique was mainly researched on.Fe3O4 magnetic nanoparticles coated with silica is acted as the substrate.Chiral reagent is N-octyl-D-glucosamine as monomer,with ofloxacin as the template molecules to prepare magnetic surface molecularly imprinted polymer.The chiral polymer can be combined with dextral ofloxacin,eventually levofloxacin was isolated.Finally by using extermal magnetic field and transmission electron microscopy (TEM),the character of magnetic surface molecularly imprinted polymer is tested,and the levofloxacin is detected by optical rotation.
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