ECHS1 is a key enzyme in fatty acid metabolism process , and its function has not been well defined . In this study , we used dual-luciferase reporter assay system and Western blot to evaluate the effects of ECHS 1 on the IFNα-induced STAT3 transcription activity when ECHS 1 was knocked down with siRNA or overexpressed . These results indicated that ECHS 1 can significantly inhibit IFNα-induced STAT3 transcription activity and sugges-ted that STAT3 might participate in the regulation of STAT 3-associated functions .%烯脂酰辅酶A水解酶（enoyl-CoA hydratase short chain 1，ECHS1），是一种脂肪酸代谢过程中的关键酶，关于其功能研究甚少。采用双荧光报告系统和Western blot等方法，分别干涉和过表达ECHS1，分析ECHS1对IFNα刺激下STAT3转录活性的影响，结果显示ECHS1能够显著抑制IFNα诱导的STAT3的转录活性，提示该基因可能参与STAT3相关功能的调控。
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