以香兰素为原料对天然产物(E)4-(3-溴-4,5-二羟基苯基)-3-丁烯-2-酮进行有机合成的研究.经过了溴代、羟醛缩合和脱甲基三个步骤.得到衍生物(E)-4-(3-溴-4羟基-5-甲氧基苯基)-3-丁烯-2-酮,为天然产物(E)4-(3-溴-4,5-二羟基苯基)-3-丁烯-2-酮的全合成提供了新方法.涉及的化合物结构经过IR,1HNMR确证.%Vanillin as raw material, studied the whole thesis of a natural product- (E)-4-(3-bromo-4,5-di-hydroxyphenyl)-but-3-en-2-one is used. The route was consist of three parts: bromination, aldol condensation and demethylation, through which ( E)-4-(3-bromo-4-hydroxy-5-methoxyphenyl)-but-3-en-2-one was synthesized. A new method about the whole thesis of (E)-4-(3-bromo-4,5-dihydroxyphenyl)-but-3-en-2-one is also given. The bromophenols mentioned above are identified by IR or ' HNMR.
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