目的:探讨子宫颈小细胞神经内分泌癌的临床与病理特点.方法:回顾性分析10例子宫颈小细胞神经内分泌癌的临床病理资料,治疗及预后.结果:10例患者平均年龄45.6岁(31~54岁),Ⅰb1期7例,Ⅰb2期1例,Ⅱa期2例.组织学示肿瘤细胞小圆形,胞浆稀少,高核浆比,缺乏核仁.免疫组化示神经内分泌标记物阳性率由高到低依次为Syn(100%,10/10),CgA(90%,9/10),CD56(85.7%,6/7),NSE(62.5%,5/8);广谱CK阳性率(80%,8/10).10例患者均行腹腔镜下全子宫、双附件切除,盆腔淋巴结清扫术.其中6例术后接受了放化疗.中位随访时间为18.6个月(8~34个月),4例死亡,2例肺转移.结论:子宫颈小细胞神经内分泌癌恶性度高,具有独特的组织学与免疫表型特点,易早期发生转移,预后差,组织病理学联合免疫组化检测可提高其诊断的准确率,并在鉴别诊断中起重要作用.%Objective:To investigate the clinicopathological characteristics of cervical small cell cancer.Meth-ods:To analyse 10 cases of cervical small cell cancer's clinical and pathological data,treatment and prognosis.Results:The average age was 45.6 years(31 to 54 years old),Ⅰb1 7 cases,Ⅰb2 1 case,Ⅱa 2 cases.Histologically,the neo-plastic cells appeared small,round in solid sheets with scant cytoplasm,hyperchchromatic nuclei and sbsence of nu-cleoli.Immunohistochemical studies showed positive rate of neuroendocrine markers for Syn(100%,10/10),CgA (80%,8/10),CD56(85.7%,6/7),NSE(62.5%,5/8),Positive rate for pan-CK was(80%,8/10).10 patients under-went extensive hysterectomy with bilateral oophorectomy and pelvic lymphadenectomy.6 patients received postoper-ative chemotherapy.The median follow-up time was 18.6 months(8 to 34 months),4 cases of death,2 cases of pul-monary metastasis.Conclusion:Cervical small cell cancer has the characteristics of highly malignant degree,early dis-tant metastasis,and poor prognosis.Histopathological joint immunohistochemical detection can improve the accuracy of diagnosis and play an important role in differential diagnosis.
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