目的：对支气管哮喘合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者进行确诊并对部分患者在常规治疗的基础上进行无创呼吸机治疗，进一步探讨无创呼吸机对支气管哮喘合并OSAHS患者的疗效。方法：哮喘患者366例进行临床诊断及临床分级（ACT评分、肺通气功能检查），对入选患者进行睡眠监测（PSG）后，将76例哮喘合并OSAHS患者随机分为组1（38例）和组2（38）例，单纯支气管哮喘患者为组3（38例）。三组患者进行常规药物治疗。组2同时给予夜间无创通气（CPAP）（经压力滴定后）治疗共12周，再对以上三组患者行ACT评分及肺功能测定。结果：哮喘合并OSAHS发病率高达56．01％，治疗前哮喘合并OSAHS患者的相关指标：BMI、ACT评分及PEF、FEV1／FVC％均较支气管哮喘患者重（P＜0．05）。哮喘合并OSAHS患者在常规用药的同时进行CPAP治疗有效（P＜0．05）。结论：哮喘合并OSAHS的重叠综合征在临床中的发病率高，且OSAHS是支气管哮喘控制不佳的重要因素之一。而支气管哮喘合并OSAHS患者在常规治疗同时联合CPAP治疗能有效控制哮喘发作。%Objective:This study of hospital patients with bronchial asthma in some patients diagnosed with OSAHS patients and non‐invasive ventilation in the treatment on the basis of conventional therapy ,to further ex‐plore the efficacy of non‐invasive ventilation in patients with bronchial asthma with OSAHS through .Methods :366 cases of clinical diagnosis and clinical classification (ACT score ,pulmonary function check ) ,for selected patients with polysomnography (PSG) after 114 patients in 76 patients with asthma with OSAHS were randomly divided into group 1 (n= 38) and group 2 (n=38) cases ,simple bronchial asthma patients group 3 (n=38) .3 groups of pa‐tients for routine drug treatment .Group 2 while giving nighttime CPAP (by pressure titration ) treatment for 12 weeks ,and then measured the ACT score and pulmonary function of patients with three or more groups .Results :The incidence of asthma with OSAHS up 56 .01 percent ,the treatment of asthma‐related indicators before the merg‐er OSAHS patients :BMI ,ACT score and PEF ,FEV1/FVC% compared with patients with severe asthma (P<0 . 05) .Asthma with OSAHS patients while conventional medicine will be non‐invasive ventilation (CPAP) therapy ef‐fective (P<0 .05) .Conclusion:Asthma with OSAHS overlap syndrome incidence in clinical and OSAHS is an im‐portant factor in asthma poorly controlled ,should be given adequate attention of clinicians to avoid misdiagnosis . The merger OSAHS patients with bronchial asthma treatment while joint regulation noninvasive respiratory therapy can effectively control asthma attacks ,thereby reducing the suffering of patients ,number of hospitalizations and treatment costs .
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