目的:探讨白癜风发病与甲状腺功能及CD4+CD25+ 调节性T细胞水平之间的相关性.方法:病例组为白癜风进展期患者80例,对照组为健康查体者50例.分别采用化学发光法检测两组受试者血清中抗甲状腺过氧化物酶抗体(TPOAb)和抗甲状腺球蛋白抗体(TGAb)水平,通过流式细胞仪测定受试者外周血中CD4+CD25+ 调节性T细胞水平,并对两组结果分别进行比较.结果:病例组患者血清中TPOAb和TGAb阳性率均高于健康对照组 (P<0.05),而病例组患者外周血CD4+CD25+ 调节性 T细胞百分率低于健康对照组 (P<0.05).结论:白癜风进展期患者存在甲状腺功能异常与细胞免疫功能异常,三者之间存在一定的相关性.%Objective:To investigate the correlation between the incidence of vitiligo with in progression period and thyroid function and the level of CD4+CD25+ T cells.Methods:Chemiluminescence was applied to test the serum levels of TPOAb, TGAb and in 80 patients with vitiligo in progression period and 50 controls.At the same time, the peripheral blood of CD4+CD25+ T lymphocytes were examined and compared.Results:The positive rate of TPOAb and TGAb in the serum of patients with vitiligo significantly higher than healthy controls (P<0.05);The level of CD4+CD25+ T cells in peripheral blood of patients in case group was lower than that in healthy control group (P<0.05).Conclusion:Patients with vitiligo in progression period with abnormal thyroid function and cellular immune function abnormalities.It is worthy of attention in clinical diagnosis and treatment.
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