Objective:To investigate the treatment effects of rifapentine on patients with pulmonary tubercu-losis and its effects on serum IL-6 ,IFN-γ,CA125 .Methods :84 patients with multi drug resistant tuberculosis in our hospital diagnosis and treatment were selected as the research object ,all patients were divided into observation group and control group accorded to the order of admission .The observation group was given the rifapentine based LHZE treatment ,the control group was given the rifampicin based RHZE treatment ,all patients were treated for 4 months .Results :The effective rate of the observation group was significantly higher than that in the control group (P<0 .05) .After treatment ,the CA125 in the observation group and the control group that were significantly lower than those before treatment (P<0 .05) ,the observation group was significantly lower than that in control group (P<0 .05) .After treatment ,the IL-6 ,IFN-γvalues in the observation group and the control group were significantly lower than before treatment (P<0 .05) ,while the observation group after treatment were significantly lower than control group (P<0 .05) .Conclusion :Rifapentine in adjuvant treatment of patients with pulmonary tuberculosis can enhance the curative effect ,inhibit the expression of CA125 ,and it can effectively reduce the content of serum IL-6 , IFN-γ,it has good application values .%目的:探讨利福喷丁对肺结核患者的治疗效果及对血清白细胞介素-6(IL-6)、IFN-γ、C A 125的影响.方法:选择耐多药肺结核病患者84例作为研究对象,按照入院顺序将所有患者分为观察组和对照组,两组都采用初治四化方案,观察组给予利福喷丁L HZE方案治疗,对照组给予利福平的RHZA治疗方案,均治疗4个月.结果:观察组显效率明显较高(P<0.05).治疗后两组C A 125值都明显低于治疗前(P<0.05),观察组治疗后的C A 125值也明显低于对照组(P<0.05).与治疗前相比,两组的IL-6、IFN-γ值都明显较低(P<0.05),治疗后,与对照组相比,观察组的IL-6、IFN-γ值明显较低(P<0.05).结论:利福喷丁辅助治疗肺结核患者能提高治疗疗效,抑制CA125的表达,且能有效降低血清IL-6、IFN-γ含量,有很好的应用价值.
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