Objectives :To explore the expression of ERCC1、VEGF-C and the level of LVD in colorectal carci-noma ,and analyze the relationship with the prognosis of colorectal carcinoma .Methods:Detection ERCC1 in 50 post-operative colorectal cancer tissues were done with immunofluorescence technique ,VEGF-C expression and LVD level in 50 postoperative colorectal cancer tissues were done with SP immunohistochemical technique ,and the data were processed by SPSS software .Results:1 .The expression of ERCC1 in postoperative colorectal cancer tissue was ob-viously lower than that in normal tissue (P=0 .01) .The expression of VEGF-C in postoperative colorectal cancer tissue was obviously higher than that in normal tissue (P=0 .000) .The level of LVD in postoperative colorectal cancer tissue was obviously higher than that in normal tissue (P=0 .000) .2 .ERCC1 expression had negative correla-tion with VEGF-C expression and LVD level (r= -0 .325 , P=0 .015 ;r= -0 .487 , P=0 .000) .3 .Five-year OS rate and DFS rate of low ERCC1 expression ,high VEGF-C expression patients were lower than those of high ERCC1 expression ,low VEGF-C expression patients(P=0 .001;P=0 .001) ,and the differences had statistical significance . Five-year OS rate and DFS rate of low ERCC1 expression ,high LVD level patients were lower than those of high ERCC1 expression ,low LVD level patients (P=0 .002 ;P=0 .001) .Conclusion :1 .The prognosis of patients with low ERCC1 expression ,high VEGF-C expression or low ERCC1 expression ,high LVD level is poor ;2 .The joint de-tection of the expression of ERCC1 and VEGF-C or the expression of ERCC1 and the level of LVD might indicate the prognosis of colorectal carcinoma .%目的:探讨结直肠癌组织中ERCC1联合VEGF-C表达及LVD水平对生存的影响.方法:选取56例II期结直肠癌术后癌组织标本,采用免疫荧光技术检测癌组织中ERCC1表达,免疫组化技术检测癌组织中VEGF-C表达和LVD水平,分析对生存的影响.结果:II期结直肠癌患者术后癌组织中ERCC1表达的平均积分光密度值低于正常肠粘膜组织(P=0.01),V EG F-C表达的平均积分光密度值高于正常肠粘膜组织(P=0.000),LVD值高于正常肠粘膜组织(P=0.000).Ⅱ期结直肠癌患者术后癌组织中ERCC1表达与VEGF-C表达及LVD水平均呈负相关(r=-0.325,P=0.015;r=-0.487,P=0.000).ERCC1低表达、VEGF-C高表达组患者5年OS率和DFS率均低于ERCC1高表达、VEGF-C低表达组(P=0.001;P=0.001),差异具有统计学意义.ERCC1低表达、LVD高水平组患者5年OS率和DFS率均低于ERCC1高表达、LVD低水平组(P=0.002;P=0.001).结论:ERCC1低表达及VEGF-C高表达或LVD高水平患者预后差.联合检测ERCC1和VEGF-C或LVD对预测结直肠癌的预后具有重要的临床意义.
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