Objective:To investigate the water channel protein L (AQP1) ,aquaporin 3 (AQP3) and inter-leukin-1 (IL-1) expression in synovium of knee osteoarthritis in the knee joint synovitis and relationship with dis-ease .Methods :80 cases of knee osteoarthritis were selected as the research object ,using immunohistochemical method to detect AQP1 in patients with synovial block .Results :Synovitis in patients with AQP1 ,AQP3 and IL-1 beta index is a significant difference (P<0 .05) ,and with the aggravation of the disease ,AQP1 ,AQP3 and IL-1 in-creased beta index ;correlation analysis showed that AQP1 ,AQP3 and IL-1 beta and the degree of synovitis of inde-xing was positively correlated (r=0 .991 ,0 .998 ,0 .997 P<0 .05) .Conclusion :AQP1 ,AQP3 and IL-1 play an im-portant role in the occurrence and development of synovitis ,but the specific clinical and pathological mechanisms still need further study .%目的:探讨水通道蛋白l(AQP1)、水通道蛋白3(AQP3)和白介素-1β(IL-1β)在膝关节炎滑膜组织中的表达意义及与膝关节滑膜炎症的关系.方法:选取收治的80例膝关节炎患者作为研究对象,采用免疫组织化学法检测患者关节滑膜阻滞中AQP1、AQP3以及IL-1β的表达水平,并采用双盲法测定累积光密度,分析各因子表达水平之间的相关性以及临床意义.结果:不同病情程度的滑膜炎患者AQP1、AQP3及IL-1β指标比较差异存在统计学意义(P<0.05),并且随着病情的加重,AQP1、AQP3及IL-1β指标均呈上升趋势;相关性分析结果显示AQP1、AQP3及IL-1β与滑膜炎症程度分度呈正相关性(P<0.05),AQP1表达与IL-1β表达呈正相关(P<0.05),AQP3表达与IL-1β表达呈正相关(P<0.05).结论:AQP1、AQP3及IL-1β在滑膜炎的发生发展过程中具有重要的应用,但其具体的临床病理机制仍需进一步深入研究.
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