Objective :To study the prevalence of the hepatic lipase gene (LIPC) promoter polymorphism (at position -514)in patients of Shanxi with nonalcoholic fatty live disease (NAFLD) ,and its relationship with the susceptibility to NAFLD .Methods :Genotype of LIPC promoter was detected with non-denaturant polyacrylamide gel electrophoresis in 96 patients with NAFLD and 98 of normal control .Body mass index ,waist-to-hip ratio (WHR) ,blood pressure ,CHOL ,HDL ,LDL ,TG and FPG of the patients were measured .Results :The propor-tions of genotypes of CC 、CT and TT at -514 of LIPC in healthy people were26 .5% 、59 .2% 、14 .2% ,respectively , whereas those in patients with NAFLD were 31 .3% 、63 .5% 、5 .2% ,The frequency of CC genotype and C allele in the NAFLD group were significantly higher than those in the control group .Conclusion :The proportions of geno-types of C/T are dominant at -514 of LIPC in patients with NAFLD and controls .Gene polymorphism of LIPC-5 14C/T is correlated with susceptibility to NAFLD of Shanxi .%目的：比较陕西地区人群中非酒精性脂肪肝（NAFLD ）患者与正常人群肝脂肪酶（HLG）-514C／T 多态性分布差异，探讨其与 NAFLD 发病易感性关系。方法：选取 NAFLD 患者96例及正常对照组98例，用非变性聚丙烯酰胺凝胶电泳进行基因多态位点检测 HLG-514位点基因型，并测量其体重指数、腰臀比、血压、胆固醇、高密度脂蛋白、低密度脂蛋白、甘油三酯、空腹血糖指数。结果：正常对照组 HLG-514 CC 、CT 、T T 基因型分别是26．5％、59．2％、14．2％，NAFLD 组31．3％、63．5％、5．2％，两组 CC 基因型频率和 C 等位基因频率比较有统计学差异。结论：肝脂肪酶-514C／T 以杂合子 C／T 基因型所占的百分比高，其基因多态性与陕西 NAFLD 患者发病有关。
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