Objective : To analyze the effects of different doses of dexmedetomidine combined with sevoflurane on maxillofacial fracture internal fixation operation anesthesia .Methods :120 cases of maxillofacial frac‐tures internal fixation surgery patients (ASA grade I ~ II) were randomly divided into 4 groups ,30 cases in each group .Object in the 4 groups using method for the same anesthesia induction and maintenance of anesthesia ,in after the success of anesthesia before surgery were given dexmedetomidine constant intravenous infusion ,which group I 0 . 3 g/kg ,group II 0 .5 g/kg ,and group III 0 .7 g/kg ,group IV normal saline .The changes of blood flow dynamics , pain ,restlessness score ,extubation ,recovery time ,nausea and vomiting were compared between the 4 groups .Re‐sults :Four groups of the patients'hemodynamics index after statistical treatment was found :and give physiological saline in group IV compared dexmedetomidine to give three groups of patients with T 4 hemodynamic parameters were statistically significant (P> 0 .05) ,which were given to dexmedetomidine 0 .5 g/kg group II patients hemody‐namics was more stable .Pain ,restlessness score were given dexmedetomidine dose decreases as ,after statistically compared with statistical significance (P< 0 .05) ,extubation ,sober and postoperative respiratory recovery time with given dexmedetomidine dose increases extend ,after statistically compared with statistical significance (P < 0 .05) . The rate of nausea and vomiting and propofol in group IV was higher than that in other 3 groups (P< 0 .05) .Con‐clusion :Dexmedetomidine set combined with sevoflurane for maxillofacial fracture internal fixation surgery the best clinical application dose of 0 .5 g/kg .%目的：探讨不同剂量右美托咪啶复合七氟醚对颌面部骨折内固定手术麻醉的影响。方法：将120例颌面部骨折内固定手术患者（ASA 分级Ⅰ～Ⅱ级）采用随机数字法分为4组，每组30例。4组患者均采用相同方法麻醉诱导及麻醉维持，于麻醉成功后手术前分别给予右美托咪啶静脉泵注，其中Ⅰ组0．3μg／kg ，Ⅱ组0．5μg／kg ，Ⅲ组0．7μg／kg ，Ⅳ组等量生理盐水。比较4组血流动力学变化，疼痛、躁动评分，拔管、清醒、恢复时间，恶心呕吐发生率及丙泊酚应用率。结果：与给予等量生理盐水的Ⅳ组比较，给予右美托咪啶的3组患者 T1～ T4的血流动力学指标比较差异均无统计学意义（P＞0．05），其中给予右美托咪啶0．5μg／kg 的Ⅱ组患者血流动力学指标更为平稳。疼痛、躁动评分均随着给予右美托咪啶剂量的增大而降低（P＜0．05），拔管、清醒及手术后呼吸恢复时间随着给予右美托咪啶剂量的增大而延长（P＜0．05）。Ⅳ组恶心呕吐及丙泊酚应用率高于其它3组（P＜0．05）。结论：右美托咪啶复合七氟醚用于颌面部骨折内固定手术麻醉的最佳临床应用剂量为0．5μg／kg 。
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