Objective:By analysis of the correlation between the serum Ang (1-7 )in the patients with rheumatic valvular heart disease and the occurrence of atrial fibrillation,to reveal the function of the Ang(1-7)in the occurrence and maintaining of atrial fibrillation and to find new targets for the prevention and treatment of atrial fi-brillation.Methods:Collect the peripheral venous blood of the patients with rheumatic heart valve disease (total 46 patients,incude 24 with AF and 22 with SR).Use ELISA method to detect the Ang (1-7),AngⅡ concentrations in the serum samples.Then,analysis the difference and correlation between the two groups.Results:In the AF group,①the diameter of left atrium was significantly greater than the SR group(60.70±3.08&48.1 5±2.1 6mm,P<0.05);②the serum concentration of Ang (1-7)was significantly lower than that in the SR group(146.05 ± 1 7. 61&321.71±36.50 pg/ml,P <0.05);③the serum concentration of AngⅡ(45.88±2.87&35.78±1.08 pg/ml,P <0.05)were obviously higher than those in the SR group.Conclusion:For the patients with rheumatic valvular heart disease,the Ang (1-7)may weaken the function of AngⅡ,and by this way inhibits the atrial remodeling,and has a protective effect on the occurrence of atrial fibrillation.%目的：：分析风湿性心脏瓣膜病患者血浆血管紧张素1-7(Ang1-7)的浓度与心房颤动发生之间的相关性,探讨 Ang(1-7)在风湿性心脏瓣膜病房颤发生与维持中的作用及房颤的预防及治疗新的靶点。方法：收取风湿性心脏瓣膜病患者(AF 组24例,SR 组22例)外周静脉血,用 ELISA法检测血清中 Ang(1-7)、血管紧张素Ⅱ(AngⅡ)的浓度,分析两组间的差别及相关性。结果：在AF 组,①左心房直径明显大于 SR 组(P <0.05)；②血清 Ang(1-7)浓度显著低于 SR 组(P <0.05)；③血清 AngⅡ浓度明显高于 SR 组(P <0.05)。结论：在风湿性心脏瓣膜病患者中,Ang(1-7)可能通过减弱 AngⅡ的作用,抑制心房的重构,对于房颤的发生具有保护作用。
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