目的：探讨血浆内皮素-1（ET-1）、氨基末端脑钠肽前体（NT-proBNP）与高血压左心室肥厚间的潜在联系，及其对高血压左心室肥厚的诊断价值。方法：对原发性高血压左心室肥厚（LVH）患者50例，健康对照组50例，采用酶联免疫吸附法检测血浆ET-1及NT-proBNP的浓度，并通过绘制ROC曲线制定ET-1、NT-proBNP对高血压左心室肥厚的诊断界值。结果：原发性高血压LVH患者血浆ET-1、NT-proBNP浓度均较正常对照组显著升高（P＜0．01）。通过绘制ROC曲线发现：以ET-1作为高血压LV H的诊断指标，最佳临界值为279．9pg/ml ，所对应的灵敏度为97％，特异度为79％；以NT-proBNP作为高血压LVH的诊断指标，最佳临界值为32．6 pg/ml ，所对应的灵敏度为64％，特异度为93％。结论：血浆ET-1、NT-proBNP水平与高血压LVH密切相关。血浆ET-1、NT-proBNP水平对高血压左心室肥厚具有较高的诊断效能。%Objective :To explore the potential relationship between plasma endothelin-1 (ET-1) ,N-ter-minal pro-brain natriuretic peptide(NT-proBNP) and hypertensive left ventricular hypertrophy (LVH) ,and evaluate the diagnostic value of plasma ET-1、NT-proBNP to hypertensive LVH .Method:Fifty hypertensive patients with LVH (27 males and 23 females) and Fifty healthy subjects (27 males and 23 females) were included in this study . The concentration of plasma ET-1 ,NT-proBNP of two group were measured by ELISA method .Comparing the difference of plasma ET-1 and NT-proBNP concentration between two groups ,and drawing ROC curves to evaluate the diagnostic value of ET-1 and NT-proBNP to hypertensive LVH .Results :The plasma ET-1 ,NT-proBNP concen-trations in hypertensive LVH group were significantly higher than those in control group (P<0 .01) .Utilizing ET-1 as hypertensive LVH diagnostic index ,the best cutoff value was 279 .9 pg/ml ,its corresponding sensitivity and spe-cificity were 97% and 79% separately ;utilizing NT-proBNP as hypertensive LVH diagnostic index ,the best cutoff value was 32 .6 pg/ml ,its corresponding sensitivity and specificity were 64% and 93% separately .Conclusion :The plasma ET-1 and NT-proBNP concentration are closely related to hypertensive LVH .The plasma ET-1 ,NT-proB-NP concentration has high diagnostic efficacy to hypertensive left ventricular hypertrophy .
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