目的：激活外周胰高血糖素样肽-1（GLP-1）受体，观察大鼠对可口蔗糖溶液摄入量及其喜好率的变化，探讨其参与摄食调控的可能机制。方法：给予大鼠腹腔注射Exendin-4（GLP-1受体激动剂）0．5μg/100g或同量生理盐水，利用双瓶选择实验，测量大鼠对8％蔗糖溶液/蒸馏水的摄入量，计算对蔗糖溶液的喜好率。结果：Exendin-4组与生理盐水组相比，大鼠摄入8％蔗糖溶液的量、对蔗糖溶液的喜好率以及3h总液体摄入量均显著减少（P＜0．05），但对蒸馏水的摄入无显著影响（P＞0．05）。结论：激动GLP-1外周受体后，可降低大鼠对蔗糖溶液的喜好程度，进而抑制对可口溶液的摄入。%Objective:To explore the effects of the periphery glucagon-like peptide-1(GLP-1) receptors in modulating sucrose solution intake in rats .Methods:The rats received intraperitoneal injection of GLP-1 receptors agonist exendin-4 or saline ,and then underwent two bottle choice test between 8% sucrose solution and distilled wa-ter .We measured the sucrose solution/distilled water intake and preference ratio of sucrose solution .Results :Com-pared with saline injection ,intraperitoneal injection of exendin-4 significantly decreased 8% sucrose solution intake , the preference ratio of sucrose solution and the total fluid intake in rats during 3h ,but had no effect on the distilled water intake .Conclusion :These results suggest that activation of the periphery GLP-1 receptors may be involved in inhibition of the tasty sucrose solution intake by reducing the preference for it .
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