Objective:To investigate the relationship between human parvovirus B 19 (HPV B19 ) infection and children who had blood system disease .Methods :PCR and ELISA methods were used to detecte HPV B19-DNA and HPV B19-IgG in child who had idiopathic thrombocytopenic purpura ,aplastic anemia or leukemia .Results :The positive rate of HPV B19-IgG was 43 .08% in patient with idiopathic thrombocytopenic purpura ,the positive rate of HPV B19-IgG was 41 .07% in patient with leukemia ,and the positive rate of HPV B19-IgG was 21 .43% in patient with aplastic anemia .There were statistical differences between the experiment groups and the control group .The positive rate of HPV B19-DNA was 40 .00% in patient with idiopathic thrombocytopenic purpura ,the positive rate of HPV B19-DNA was 27 .68% in patient with leukemia ,and the positive rate of HPV B19-DNA was 21 .43% in patient with aplastic anemia .Conclusion :HPV B19 infection have relationship with some children who have blood system dis-eases in northwest region of China .%目的：探讨我国西北地区血液系统疾病患儿人细小病毒B19（H PV B19）感染情况及两者的相关性。方法：对特发性血小板减少性紫癜、再生障碍性贫血和白血病患儿的外周血分别采用PCR方法检测HPV B19-DNA和ELISA方法检测HPV B19-IgG。结果：特发性血小板减少性紫癜患儿HPV B19-IgG阳性率为43．08％（28/65），白血病患儿 HPV B19-IgG阳性率为41．07％（46/112），病例组较对照组比较有极显著性差异（P＜0．01）；再生障碍性贫血患儿 HPV B19-IgG阳性率为21．43％（6/28），病例组较对照组比较有显著性差异（ P＜0．05）。65例特发性血小板减少性紫癜患儿HPV B19-DNA阳性率为40．00％（26/65）；28例再生障碍性贫血患儿 HPV B19-DNA阳性率为21．43％（6/28）；112例白血病患儿 HPV B19-DNA 阳性率为27．68％（31/112）；对照组 HPV B19-DNA检测均为阴性。结论：HPV B19感染与我国西北地区部分血液系统疾病患儿发病相关。
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