Objective: To investigate the guiding significance of Ti/Ttot (inspiratory time/ respiratory cycle time) and f/VT (frequency/ tidal volume ratio) on weaning from ventilator in patients with COPD. Methods:Ti/ Ttot,f/VT, VT (tidal volume) ,RR (respiratory rate), VE (minute ventilation) and MIP (maximal inspiratory pressure) of 43 patients with COPD in EICU were monitored by the breath tester BICORE-CP100. Then,comparisons were done between tne successful weaning group and tne failed group. RR and VT were monitored at tne very beginning of SPT (spontaneous breathing trial). Results:In the successful weaning group of 28 patients,Ti/Ttot 0. 31 + 0. 03 and,f/VT 92+12bpm/L. In the failed group of the other 15 patients,Ti/Ttot 0. 38 + 0. 02 and, f/VT of 104 ± 9bpm/L. Compared with the successful weaning group,Ti/Ttot,f/VT,MIP and VE in the failed group were higher significantly (.P＞0. 05). Conclusion: Ti/Ttot and f/VT both had important guiding significance on weaning from ventilator, while each individual one is still non-sensitive indicator, so we should adjust the treatment also according to the clinical indexs.%目的:探讨Ti/Ttot(吸气时间分数)和f/VT(浅快呼吸指数)在COPD(慢性阻塞性肺病)机械通气患者撤机中的指导意义.方法:选择EICU(急诊重症监护病房)的43例COPD撤机患者,应用BICORE-CP100呼吸监测仪床边监测病人Ti/Ttot、f/VT和常规撤机指标VT(潮气量)、RR(呼吸频率)、VE(每分钟通气量)、MIP(最大吸气压),撤机成功组与撤机失败组指标评分进行相互比较.其中,RR、VT在SPT(自主呼吸试验)开始时测定,观察其对撤机的指导意义.结果:撤机成功组28例,Ti/Ttot 0.31±0.03,f/VT 92±12;撤机失败组15例,Ti/Ttot 0.38±0.01,f/VT 104±9.撤机失败组Ti/Ttot、f/VT、MIP、VE均明显高于撤机成功组,相互比较有显著差异(P＜0.05);VT明显低于撤机成功组,相互比较有显著差异(P＜0.05).结论:Ti/Ttot和f/VT对撤机都有重要指导作用,但单个仍非敏感指标,对COPD患者应同时结合临床指标更为可靠.
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