目的:探讨野生型p53活化片断1(p21WAF1)基因与卵巢癌临床病理特征(组织学分级、转移、肿块大小)的相关性.方法:随机选择45例卵巢癌患者的卵巢癌和癌旁组织标本,SP法检测其p21WAF1蛋白表达,分析p21WAF1基因与卵巢癌临床病理特征(组织学分级、转移、肿块大小)的相关性.结果:p21WAF1在卵巢癌和癌旁组织中阳性表达率分别为15.6％和68.9％,两者比较有极显著性差异(P＜0.01)；p21WAF1蛋白阳性表达率与卵巢癌不同的临床病理特征(组织学分级、转移、肿块大小)有相关性(P＜0.01).结论:p21WAF1基因与卵巢癌临床病理特征(组织学分级、转移、肿块大小)有关.%Objective: To study the correlation of expression of p21WAF1 gene with the clinical pathological feature ( histological grade, metastasis and tumor size) of epithelial ovarian carcinoma (EOC). Methods: P21WAF1 protein expression in the cancer tissue and peri-cancer tissue samples of the 45 cases patients with EOC e-lected by a random methods were detected by the immunicytochemical method(SP). To study the correlation of expression of p21WAF1 gene with the clinical pathological feature (histological grade, metastasis and tumor size) of EOC. Results: The positive rates of p21WAF1 proteins in the cancer tissue and peri-cancer tissue samples were re-spectivelyl5. 6% and 68. 9%. The difference between them was significant (P<0. 01). There was correlation between expression of p21WAF1 protein expression with the clinical pathological feature(histological grade, metastasis and tumor size)of EOC(F<0. 01). Conclusion: There is correlation between p21WAF1 gene with the clinical pathological feature(histological grade, metastasis and tumor size)of EOC.
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