目的:观察Rho激酶抑制剂预防心脏介入诊疗术后并发症的临床疗效.方法:对住院经桡动脉行冠状动脉介入诊疗的患者481例于术后拔管前经鞘内注入相应药物,A组予以法舒地尔5mg,B组予以硝酸甘油200μg,C组予以生理盐水对照,观察是否出现桡动脉痉挛、局部血肿、急性血管闭塞或狭窄等并发症.结果:经桡动脉介入治疗时,应用Rho激酶抑制剂法舒地尔可以更有效防治术后并发症发生,且不良反应发生率低.结论:Rho激酶抑制剂法舒地尔预防心脏介入诊疗术后并发症安全有效.%Objective: To observe the clinical effect of Rho Kinase inhibitors in preventing complications after trans-radial coronary intervention(TRI). Methods: 481 hospitalized patients were placed scabbard successfully ,in the diagnosis and treatment of coronary intervention by the radial , injected the corresponding drugs to prevent complications before extubation, group A Fasudil 5 mg, group B nitroglycerin 200 μg, group C 0. 9 % NaCl 10ml, observed whether there was the thradial spasms , local hematoma and acute vascular occlusion or stenosis complications, ect. Results;In the radial intervention, the application of Rho Kinase inhibitors could be more effective on prevention and control the occurrence of radial complications(P<0. 05) ; and lower incidence in adverse reactions(P<0. 05). Conclusion: Rho Kinase inhibitors is safe and effective in diagnosis and treatment of interventional heart surger-y to prevent radial complications, and it is worth popularizating and applicating in the clinical field of ardiovascular intervention.
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