目的:研究海拔4500m的高高原地区低氧条件下, 腹腔镜胆囊切除术 (LC) 与传统开腹胆囊切除术 (OC) 对患者术后肝功能及炎症因子的影响.方法:将西藏阿里地区人民医院收治的88例胆囊结石患, 随机分为LC组 (42例) 和OC组 (46例), 分别分析两组患者术后第1天和第5天肝功能 (ALT、AST、ALP、TBIL) 及炎症因子 (CRP、IL-6、IL-8) 指标的变化.结果:两组患者术后第1天的ALT、AST、TBIL均比本组术前升高, 而ALP低于术前, 差异有统计学意义 (P0.05) ;术后第1天、第5天两组间的肝功能指标差异无统计学意义 (P>0.05) .两组患者术后第1天的炎症因子水平均较本组术前升高, 差异有统计学意义 (P0.05), LC组与OC组间, 术后第1天及第5天的炎症因子比较, 差异有统计学意义 (P0.05).Liver function index were show no significant difference between the two groups at 1 st day and 5 th days after operation (P>0.05).For the levels of Inflammatory factors (CRP, IL-6 and IL-8) were significantly higher than those before surgery in two groups, respectively (P0.05).The levels of Inflammatory factors were show significant difference between the two groups at 1 st day and 5 th days after operation (P<0.05).Conclusions:Both LC and OC decrease liver function and increase the level of inflammatory cytokines, but the effect of LC on inflammatory factors is greater than that of OC.LC surgery has little trauma to the abdominal wall compared with OC surgery.LC operation can be promoted in high altitude areas.
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