Objective To investigate the expression of glucose regulated protein 78 ( GRP78) and its significance in the renal carcinoma tissues.Methods The immunohistochemistry ( IHC) method was used to detect the expression of GRP78 in 108 cases of renal carcinoma tissues and para-carcinoma tissues.According to the expression and percentage, the expression of GRP78 was divided into the positive expression and negative expression.The relationships between the GRP78 expression and clinical pathologic features of patients were analyzed.The Kaplan-Meier was used to calculate the overall survival (OS) of different expression of GRP78, and the Log-rank test was applied to compare.We adopted the Cox regres-sion model to analyze the influence factors of OS.Results The positive rate of GRP78 expression in the tumor tissue was 72.3%(78/108), 19.4%(21/108) in para-carcinoma tissues, and significant difference was found between them (P<0.05).The expression of GRP78 in the renal carcinoma was correlated with lymph node metastasis and clinical stage (all P<0.05), and was not related with sex, age, diameter of tumor, pathological type and Fuhrman stage (all P>0.05). The overall survival time of patients with positive and negative expression of GRP78 in renal carcinoma was (57.9 ±8.6) and (77.2 ±7.9) months, respectively.The overall survival time of patients with positive GRP78 expression was signifi-cantly lower than that of patients with negative GRP78 expression (P<0.05).Univariate analysis demonstrated GRP78 ex-pression, clinical stage, grade of Fuhrman and lymph node metastasis were the influence factor for OS;Multivariate analy-sis confirmed that the positive expression of GRP78, grade of Fuhrman and lymph node metastasis were three independent prognostic factors for OS (all P<0.05).Conclusion GRP78 expression was increased in the renal carcinoma and its high expression was related with OS of patients.%目的：探讨肾癌组织中葡萄糖调节蛋白78（GRP78）的表达及意义。方法采用免疫组化SP法检测108例肾癌患者癌组织及癌旁正常组织中GRP78表达。根据癌组织染色结果分为GRP78阳性表达和阴性表达，分析不同GRP78表达与患者临床病理特征的关系。采用Kaplan－Meier法计算不同GRP78表达者总生存期（OS），Log－rank检验进行比较。釆用Cox比例风险回归模型分析OS的影响因素。结果肾癌组织中GRP78阳性表达率为72．3％（78／108），癌旁正常组织的阳性表达率为19．4％（21／108），二者比较P＜0．05。 GRP78阳性表达与淋巴结转移、临床分期有关（P均＜0．05），与性别、年龄、肿瘤直径、病理类型、Fuhrman核分级无关（P均＞0．05）。肾癌组织GRP78阳性表达者与阴性表达者OS分别为（57．9±8．6）、（77．2±7．9）个月，二者比较P＜0．05。单因素Cox比例风险回归模型分析显示，GRP78表达、临床分期、Fuhrman核分级、淋巴结转移与OS有关（P均＜0．05）；多因素Logistic回归分析显示，GRP78阳性表达、Fuhrman核分级高、有淋巴结转移是OS的独立影响因素（P均＜0．05）。结论 GRP78在肾癌组织中表达升高，其高表达与患者OS有关。
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