Objective To explore the levels and clinical significance of copeptin in acute exacerbation of chronic ob -structive pulmonary disease (AECOPD).Methods 90 subjects with AECOPD were divided into on respiroatory faicure group (n=43), respiratory failure group (n=47),and forty healthy as a control group .The levels of serum copeptin of all AECOPD patients before and after treatment and control group were detected .Results Before treatment , the serum copep-tin of the respiratory failure group was(25.31 ±16.33)pmol/L, on respiroatory faicure group was(10.34 ±4.37)pmol/L, all of them were higher than the control group (4.93 ±1.20)pmol/L (all P<0.01),and the respiratory failure group was higher than the no respiratory failure group (P<0.01);after treatment, the serum copeptin of the respiratory failure group was(5.93 ±3.37)pmol/L, on respiroatory faicur group was (5.47 ±1.60)pmol/L,all of them were significantly reduced (P<0.01).Conclusion The levels of serum copeptin is significantly increased in AECOPD patients .The serum copep-tin is expected to be a useful biological index to estimate the AECOPD .%目的：探讨慢性阻塞性肺疾病急性加重期（ AECOPD）患者血清和肽素水平的变化及其临床意义。方法AECOPD患者90例，根据有无呼吸衰竭将患者分为无呼吸衰竭组43例、呼吸衰竭组47例，另取同期40例健康体检者为对照组。测定AECOPD患者治疗前后及对照组血清和肽素水平。结果治疗前呼吸衰竭组、无呼吸衰竭组血清和肽素分别为（25．31±16．33）、（10．34±4．37）pmol／L，均明显高于对照组（4．93±1．20）pmol／L（P均＜0．01），且呼吸衰竭组明显高于无呼吸衰竭组（P＜0．01）。治疗后呼吸衰竭组、无呼吸衰竭组血清和肽素分别为（5．93±3．37）、（5．47±1．60）pmol／L，均较治疗前显著降低（P均＜0．01）。结论 AECOPD患者血清和肽素水平明显升高，有望成为AECOPD诊断及评价治疗效果的一个有用生物指标。
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