目的 分析瓣膜置换术后机械通气时间延长(≥48 h)的危险因素.方法 回顾我院2010年1月～2011年8月行心脏瓣膜置换术的518例患者的临床资料,并对术后机械通气辅助呼吸时间延长(≥48 h)的危险因素进行分析.结果 手术后机械通气时间超过48 h的患者72例,发生率13.9％.单因素分析结果表明,患者的年龄、心功能分级、术前血浆BNP水平、射血分数、肺动脉收缩压、同期行冠状动脉旁路移植手术、主动脉内球囊反搏支持、体外循环时间、主动脉阻断时间、置换瓣膜的数量、术后使用多巴胺≥10 μg/( kg·min)以及术后使用肾上腺素与患者术后机械通气时间延长相关(P＜0.05或P＜0.01),上述因素进入二元逐步Logistic回归分析,结果显示患者的心功能分级、肺动脉收缩压和术后使用多巴胺≥10μg/(kg·min)与术后机械通气时间延长独立相关(P＜0.05或P＜0.01).结论 瓣膜置换术后机械通气时间延长的影响因素较多,其中患者的心功能分级、肺动脉收缩压和术后使用多巴胺≥10μg/(kg·min)是患者术后机械通气时间延长的独立危险因素.%Objective To evaluate the clinical risk factors of prolonged mechanical ventilation after valve replacement surgery. Methods A total of 518 patients who underwent valve replacement between Jan 2010 and Aug 2011 were studied retrospectively. And the risk factors of prolonged mechanical ventilation ( ≥48 h) after valve replacement surgery were e-valuated. Results Prolonged mechanical ventilation occurred in 13.9% patients after valve replacement surgery. Univari-ate analysis showed that, patients' age, cardiac function, BNP level, ejection fraction, pulmonary artery pressure, concomitant CABG surgery, 1ABP usage, cardiopulmonary bypass time, aortic cross-clamp time, number of valve replacement, use of dopamine ≥10 ( kg·min) and use of epinephrine are related to prolonged mechanical ventilation after valve replacement surgery (P <0.05 orP<0. 01). Binary logistic regression analysis showed that, cardiac function, pulmonary artery pressure and use of dopamine ≥10 μg/( kg·min) are independently associated with prolonged mechanical ventilation after valve replacement surgery (P <0.05 or P <0.01). Conclusion Patients' cardiac function, pulmonary artery pressure and use of dopamine ≥10μg/( kg·min) are risk factors of prolonged mechanical ventilation after valve replacement surgery.
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