Objective To study the expression of PINCH protein and COX-2 protein in gastric carcinoma tissues, and explore its significance. Methods SP imunohistochemical method was adopted to detect the expression of PINCH protein and COX-2 protein in 30 cases normal gastric mucous tissue and 73 cases gastric carcinoma. Results PINCH and COX-2 positive expression ratio in gastric carcinoma tissues were 75. 34% , 76. 71% .but 43. 30% . 40. 00% in normal gastric mucous, allP<0. 05. PINCH and COX-2 expression was obviously correlated with lymph node metastasis , allP<0.05. The expression of PINCH was positively correlated to COX-2 ( r = 0. 587, P < 0. 05 ). Conclusions The expression of PINCH and COX-2 increase in gastric carcinoma. It may participate in invasion and metastasis of gastric carcinoma.%目的 观察胃腺癌组织中PINCH蛋白、环氧合酶(COX)-2蛋白的表达变化,并探讨其临床意义.方法 采用免疫化SP法检测30例正常胃黏膜组织和73例胃腺癌组织中的PINCH、COX-2蛋白.结果 胃腺癌组织中PINCH、COX-2蛋白阳性表达率分别为75.34％、76.71％,明显高于正常胃黏膜组织的43.30％、40.00％P均＜0.05.胃腺癌组织中PINCH、COX-2阳性表达与淋巴结转移有关(P均＜0.05).胃腺癌组织中PINCH、COX-2的表达呈正相关性(r =0.587,P＜0.05).结论 胃腺癌组织中PINCH、COX-2高表达,其可能参与了胃腺癌的发生和转移.
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