Objective To explore the alterations of pulmonary surfactant protein-A, B, C and D in serum in children with severe pneumonia caused by 2009 pandemic H1N1 influenza virus. Method Serum pulmonary surfactant protein-A, B, C and D were measured in 8 severe H1N1 pneumonia children and 20 healthy children with ELISA as well as peripheral white blood cells, prealbumin and albumin. Results Serum levels of pulmonary surfactant protein-A, B, C and D in severe H1N1 pneumonia children were significantly increased compared with healthy ones. The severe pneumonia children' s white blood cells, prealbumin and albumin were greatly decreased, but D-dimer was significantly higher than that in healthy children. Conclusion Serum pulmonary surfactant protein-A, B, C and D may be used as valuable biomarkers for the e-valuation of lung injury and its severity in children with severe H1N1 pneumonia.%目的 探讨流行性甲型H1N1流感(简称甲流)重症肺炎患儿肺表面活性蛋白A、B、C、D在血清含量变化的特点,寻找肺组织损伤的生化指标.方法 采用ELISA方法检测8例甲流重症肺炎患儿(甲流组)和20例健康儿童(对照组)血清肺表面活性蛋白A、B、C、D含量,同时化验前白蛋白和白蛋白等.结果 甲流组血清肺表面活性蛋白A、B、C、D含量高于对照组(P均＜0.05)；外周血白细胞、血浆前白蛋白、白蛋白等低于对照组(P均＜0.05)；二聚体高于对照组(P＜0.05).结论 甲流重症肺炎患儿血清肺表面活性蛋白A、B、C、D含量可作为肺组织损伤严重程度的检验指标.
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