The serum TT３、FT3、rT３、PRA、Ang Ⅱ were measured in 34 CHFpatients(experimental sujects) and 15 normal subjects with RIA. The LVEFs of patients were investigated by dopper Echocardiography. Serum TT3、 FTa of experimental subjects were significant lower than that of the control (P＜0.001 ). The serum rT3,PRA and Ang Ⅱ of the CHFs were higher than that of the controls(P＜0. 001). In multipe regression analysis,serum TT3 and FT3 are positively related to LVEF,and the serum rT3,PRA and Ang Ⅱ are inversely related to LVEF,and the serum PRA, Ang Ⅱ are inversely related to TT3. The results indicated that low serum TT3,FT3 and high serum rT3,PRA and Ang Ⅱ are the pathophysiology of CHF. It is important to measure FT3 ,TT3,rT3,PRA and Ang Ⅱ to estimate the heart function in CHF patients.%采用放免法测定34例CHF患者(观察组)和15例正常人(对照组)的血清甲状腺激素、PRA和AngⅡ水平，同时采用彩色多普勒超声心动图仪测定34例CHF患者的LVEF。结果：观察组的血清总三碘甲状腺原氨酸(TT3)、游离T3(FT3)含量均较对照组显著降低(P＜0.001)；反T3(rT3)、PRA、AngⅡ水平均显著增高(P＜0.001)。观察组血清TT3、FT３含量与LVEF均呈显著正相关，rT３PRA、AngⅡ水平与LVEF均呈显著负相关，PRA、AngⅡ水平与血清TT3含量均呈显著负相关。表明血清TT3、FT3降低及rT３、PRA、AngⅡ升高是CHF的病理生理特征之一，检测上述指标对判断心功能状态具有重要临床价值。
展开▼
