Based on the analysis of the design for the multi-tower structure with a large base, the paper points out it is better to calculate the inte- grated model and the discrete model respectively, and undertakes the design by taking the unfavorable results, illustrates that it is more accurate to calculate other parameter with the integrated model except the calculation of the building＇ s period ratio and the calculation results with the integrated and discrete models are not obvious when the floor numbers and the stiffness of those towers are close, and proves the conclusion will be the reference for the similar projects in future.%通过对某多塔大底盘的结构设计分析，指出宜按整体模型和离散模型分别进行计算，并取不利结果进行设计；除塔楼周期比计算外，其余参数用整体模型计算较准确，且各塔楼的层数、刚度接近时，整体模型和离散模型的计算结果差异不明显，得出的相关结论为今后类似工程提供了借鉴。
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