Objective To investigate the relationship between psychotic symptoms and hormone levels at different menstrual periods in female patients with schizophrenia aged 18-35.Methods Sixty female schizophrenia patients were recruited in this study.The levels of sex hormone and BPRS scores of the subjects were measured in the menstrual period and after the menstrual period.Results The estradiol levels of the subjects who were in the menstrual period were significantly lower than that after the menstrual period in female patients with schizophrenia (P<0.05).The psychotic symptoms and the BPRS scores of the subjects who were in the menstrual period were significantly higher than that in non-menstrual period(P <0.05).Conclusion The low level of estradiol in the menstrual period has a significant correlation with the mental symptoms in female patients with schizophrenia aged 18-35,and the psychosis symptoms are more obvious.%目的 探讨18~35岁女性精神分裂症患者在不同月经期其精神病性症状与激素水平的相关性.方法 选择60例女性精神分裂症患者作为研究对象,分别测定患者经期和经期后的各项性激素水平、简明精神病评定量表(BPRS)评分等.结果 女性精神分裂症患者经期时的雌二醇水平显著低于经期后,差异有统计学意义(P<0.05);女性精神分裂症患者经期时的精神病性症状、BPRS总分高于经期后,组间比较差异有统计学意义(P<0.05);结论 月经期低雌激素水平与18~35岁女性精神分裂症患者的精神症状具有明显的相关性,且其精神病性症状更为突出.
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