Objective To investigate the clinical efficacy of sequential treatment of early and middle stage knee osteoarthritis .Methods Sixty early and middle stage knee osteoarthritis cases of Department of Rheumatism , Bone Joint in our hospital were randomly divided into A and B groups ( n=30) .A group:sodium hyaluronate in‐jection in knee joint cavity by knee eye injection+functional training therapy ;B group:sodium hyaluronate injec‐tion in knee joint cavity by knee eye injection+small knife treatment .We followed up for 6 months and observed knee pain score ,Lysholm score of knee joint function ,and quality of life score I in two groups .Results VAS and Lysholm scores of A group were 2.6 ± 0.8 and 71 ± 6 ,respectively .VAS and Lysholm scores of B group were 1.7 ± 0.8 and 76 ± 6 ,respectively .Compared with A group ,VAS scores decreased and Lysholm scores increased in B group (P< 0.05) .Before treatment ,there were no statistical difference in WHOQOL‐100 health related quality of life scores (physiology ,psychology ,independence ,social relationship ,environment ,spirit religious be‐lief) in two groups(P>0.05) .Following up 6 months after treatment ,compared with before treatment ,WHO‐QOL‐100 health related quality of life scores (physiology ,psychology ,independence ,social relationship ,environ‐ment ,spirit religious belief) significantly increased in two groups (P<0.05) .Scores of B group is better than that in A group (P<0.05) .Following up 6 months after treatment ,A group′s excellent rate of knee joint func‐tion (77% ) was significantly lower than that of B group(93% ) (P<0.05) .Conclusion Compared with sodium hyaluronate injection in knee joint cavity by knee eye injection+ functional training therapy ,sodium hyaluronate injection in knee joint cavity by knee eye injection+ small knife treatment has better clinical efficacy on knee osteo‐arthritis patients of early and middle stage .%目的：探讨采用序贯综合治疗对早中期膝骨关节炎的临床疗效。方法选取我院收治的60例早中期膝骨关节炎患者，采用随机数字表法分为2组，每组30例。A组采用膝眼入路行膝关节腔注射玻璃酸钠＋功能训练治疗，B组采用膝眼入路行膝关节腔注射玻璃酸钠＋小针刀松解治疗，比较2组患者治疗前与治疗2个疗程之后的膝关节疼痛评分、Lysholm膝关节功能评分及治疗结束随访6个月后患者的生活质量评分变化情况。结果治疗后A组的VAS疼痛评分（2.6±0.8）分明显高于B组（1.7±0.8）分），Lysholm评分（71±6）分明显低于B组（76±6）分，差异均具有统计学意义（P＜0.05）；治疗前2组患者的世界卫生组织健康相关生活质量量表（WHOQOL‐100）评分各维度：生理、心理、独立性、社会关系、环境、精神／宗教信仰评分差异均无统计学意义（P＞0.05）；治疗后随访6个月，2组患者的生理、心理、独立性、社会关系、精神／宗教信仰评分较治疗前均明显提高（P＜0.05），且B组较A组提高更加明显（P＜0.05）；治疗结束后，2组患者均随访6个月，A组的膝关节功能优良率77％明显低于B组的93％（ P＜0.05）。结论早中期膝骨关节炎患者采用膝眼入路行膝关节腔注射玻璃酸钠＋小针刀松解治疗较膝眼入路行膝关节腔注射玻璃酸钠＋功能训练治疗具有更加显著的临床效果。
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