Objective To establish a rabbit model of deep vein thrombosis by a new method ,and to observe its characteristics of concomitant inflammatory response .Methods Thirty New Zealand white rabbits were ran‐domly divided into two groups .Sham surgery by exposing of vena cava was performed in control group .Inferior vena cava thrombosis model was established by temporary blocking blood flow in inferior vena cava and incomplete ligation .At 3 days ,7 days and 14 days after modeling ,general observation ,ultrasound and pathological examina‐tion were taken .To count the local inflammatory cells number of model group lesions ,and detect the contents of inflammatory cytokines IL‐6 and MCP‐1 in plasma .Results The success rate of operation was 100% ,one rabbit died due to diarrhea after surgery in modeling group ,the mortality was 3% .Precise and stable thrombosis were confirmed in model group by general observation ,ultrasound examination and pathological examination ;There was no obvious thrombosis in control group .In model group ,inflammatory cells gathered in the vein wall obvious‐ly ,and different cells number changed with time ;Plasma inflammatory cytokines such as IL‐6 ,MCP‐1 increased significantly .Conclusion By the new method which blocked blood flow temporarily and ligated the vein incom‐pletely ,a stable model of venous thrombosis is feasible in rabbits ;Inflammation of the vein thrombosis is continu‐ous ,systemic and from acute to chronic .%目的：应用新的方法建立家兔深静脉血栓模型，并观察其伴发炎症反应的特点。方法取新西兰白兔30只，随机分为对照组12只，血栓模型组18只。对照组家兔仅行开腹游离后腔静脉，模型组家兔后腔静脉行不完全结扎加暂时性阻断术建立静脉血栓模型。建模后3、7、14 d分别进行大体观察、多普勒超声、组织病理学检查，并进行2组比较；计数模型组家兔病变静脉局部炎症细胞数，测定其血浆炎性因子白细胞介素‐6（IL‐6）、单核细胞趋化蛋白‐1（MCP‐1）的含量。结果造血栓模型手术顺利，成功率100％；术后1只家兔因腹泻死亡，死亡率3％。大体观察、超声检查及病理检测均证实模型组家兔血栓形成确切、稳定；而对照组无明显血栓形成。模型组家兔病变部炎症细胞聚集明显，不同细胞的数量随时间而变化；血浆炎性因子IL‐6、MCP‐1明显增高。结论后腔静脉不全结扎联合暂时性阻断是一种新的方法，可建立稳定的深静脉血栓动物模型；静脉血栓伴发的炎症具有持续性、全身性和急性向慢性转变的特点。
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