Objective To observe the clinical efficacy of different doses of glucocorticoids combined with aminophylline in the treatment of chronic obstructive pulmonary disease (COPD) .The present experiment was to explore the effects of glucocorticoids combined with aminophylline on the lung function and quality of life in pa-tients .Methods According to the inclusion criteria ,90 subjects were enrolled and divided into two treatment group (large doses of glucocorticoids with aminophylline ,small doses of glucocorticoids with aminophylline ) and a con-trol group .The FEV1 ,FVC and SGRQ were observed after three-month treatment.Results After the treatment for three months ,The pulmonary function (FEV1 ,FVC) and 6-MWD of both groups increased .The SGRQ de-creased .The differences were statistically significant ( P <0 .05) .Compared with the large and small doses of glucocorticoid combined aminophylline ,the large doses group improved significantly ( P<0 .05) .Conclusion The different doses of glucocorticoid combined aminophylline can improve pulmonary function and clinical symptom in COPD patients .And the large doses of glucocorticoids with aminophylline is possibly more efficacious than normal doses for COPD patients.%目的：观察不同剂量糖皮质激素（GCS）联合氨茶碱治疗慢性阻塞性肺疾病（COPD）患者的临床疗效，探讨两药联合对患者肺功能和生活质量的影响。方法根据标准纳入90例受试者，分为高剂量GCS联合氨茶碱组（高剂量组）、低剂量GCS联合氨茶碱组（低剂量组）与氨茶碱对照组（对照组）。观察用药3个月后3组患者的肺功能[第1秒用力呼气容积（FEV1）、用力肺活量（FVC）、6 min步行距离（6-MWD）、圣乔治呼吸问卷（SGRQ ）总分]变化情况。结果对比各组用药前后的变化，用药3个月后3组肺功能指标 FEV1、FVC、6-M WD较用药前升高，SGRQ评分较用药前降低，差异具有统计学意义（ P ＜0．05）。高剂量组治疗效果优于低剂量组，差异具有统计学意义（ P ＜0．05）。结论不同剂量 GCS联合氨茶碱均能改善COPD患者肺功能，且高剂量GCS联合氨茶碱较常规剂量疗效更佳。
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