以金黄色葡萄球菌为指示菌，采用琼脂扩散法，在不同温度、酸碱度、盐浓度、金属离子条件下，对FLa－AA－FLc抗菌肽抑菌活性的变化情况进行了深入研究。结果发现：FLa－AA－FLc抗菌肽对热和pH不敏感，醋酸铵能显著降低其抑菌活性，金属离子除Fe3＋外，其他金属离子对其抑菌活性没有影响。本项试验为FLa－AA－FLc抗菌肽的生产工艺和使用方式研究提供依据。% The aim of this study was to examine the antibacterial activity of FLa -AA-FLc .The staphylococcus aurous was used to examine the antibacterial activity of FLa-AA-FLc using the agar diffusion method .This experiment was carried out under different physical and chemical conditions such as temperature ,pH ,salt concentrations and metal cations .The results showed that antimicrobial peptide FLa -AA-FLc was not sensitive to pH and high temperature ,ammonium acetate could remarkably reduce the antibacterial activity of FLa -AA-FLc ,and Fe3+ affect-ed the antibacterial activity of FLa-AA-FLc .It will provide theoretical basis for the production process and application of FLa -AA-FLc .
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