In order to regulate the processing technology of the Pieces of Asarum heterotropoides Fr.Schmidt var. mandshuricum (Maxim.) Kitag., the attenuating process of the pieces was investigated. In this study, taking the rinsing time, soaking time, drying temperature, drying method (dry and drying) and drying time as the investigation factors, taking aristolochic acid I, aspartate, extract, water content and volatile oil as indicators, the processing parameters of the Pieces of A. heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag. were determined. The results shows that after the 5 min rinsing, the sirloin is cut into sections, 24.6 ℃dry 24 h or 5 min rinse, cut into sections, 25.0-35.0℃8 h drying, you can get the Pieces of A. heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag. that meet the requirements; When the rinsing time of A. heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag. is increased to 48 h, 24.6 ℃dry 48 h, the attenuating process of the saponin of the Pieces of A. heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag. can be obtained. The processing technology studied in this paper is more practical in actual production, at the same time, by adjusting the processing parameters, the content of aristolochic acid I in the pieces can also be reduced, and the effect of attenuation can be achieved.%为规范北细辛饮片的炮制工艺, 考察饮片的减毒工艺, 本研究以药材润洗时间、浸泡时间、干燥方式 (阴干和烘干) 、干燥温度、干燥时间为考察因素, 以马兜铃酸I、细辛脂素、浸出物、含水量和挥发油为指标, 确定北细辛饮片的炮制工艺参数.结果表明, 北细辛药材经过5 min润洗、24.6℃阴干24 h或5 min润洗、25.0～35.0℃8 h烘干, 即可得到符合要求的北细辛饮片;将北细辛药材的润洗时间增加至48 h, 24.6℃阴干48 h, 可作为北细辛饮片的减毒工艺.本试验研究的炮制工艺在实际生产中更具实用性, 同时, 通过调整炮制参数也可降低饮片中马兜铃酸I的含量, 实现减毒的作用.
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