Transforming growth factor-β(TGF-β)is a multifunctional cytokine,which performs many crucial cellular functions in cell biological processes such as cell proliferation and differentiation,extracellular matrix synthesis and tissue repair.Recent studies have shown that TGF-β plays an important role in the development of the mandibular condylar cartilage.It mediates local functional stimulus in the remodeling of condylar cartilage and has a potential role in the development of TMJ osteoarthritis,protecting the articular carti-lage.The purpose of this review is to discuss effects of TGF-β on the development,remodeling growth and degradation process of man-dibular condylar cartilage.%转化生长因子β(transforming growth factor beta,TGF-β)是一种多功能的细胞因子,广泛参与细胞的多种生物学过程,如细胞增殖分化、胞外基质的合成和组织修复等.近年来的研究发现,髁突软骨的发育必须有TGF-β的参与,TGF-β可介导局部的功能刺激作用,参与髁突软骨的适应性改建,与髁突软骨退行性病变相关.本文就TGF-β在髁突软骨发育、改建和退行性关节病中的作用作一综述.
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