Objective To compare the caries⁃preventive effect between pit and fissure sealant and fluor protector on first permanent molars pit and fissure caries. Methods The first permanent molars of 300 children were treated respectively with light cured pit and fissure sealant (left side) and fluor protector (right side), and incidence of caries was examined respectively after 0.5, 1.0 and 2.0 years. Results No significant differences of incidence of caries were detected after 0.5, 1.0 and 2.0 years. Conclusion Both pit and fissure sealant and fluor protector have good clinical effect on preventing caries.%目的：比较窝沟封闭和氟保护漆预防学生年轻第一恒磨牙窝沟龋的效果。方法应用两种材料对300名小学生进行上下颌第一恒磨牙同体对照封闭试验，左侧使用光固化窝沟封闭剂，右侧使用氟保护漆，于0．5、1．0、2．0年观察3次龋病发生情况。结果0．5、1．0、2．0年左右侧第一恒磨牙龋齿发生率均无统计学意义。结论窝沟封闭和氟保护漆均有良好的防龋效果。
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