Objective To evaluate the effect of neodymium-doped yttrium aluminium garnet (Nd:YAG)laser assisting initial thera-py of periodontal diseases by Meta-analysis.Methods The periodical literature,conference paper and academic dissertation of Chinese were scanned by electronic retrieval and manual search,and then the clinical studies which compared Nd:YAG laser assisting initial therapy of periodontal diseases to initial therapy of periodontal diseases alone were collected.According to inclusion and exclusion crite-ria,the quality assessment of these included studies,the data extraction were done and the heterogeneity test,the Mate-analysis were conducted.We also test the publication bias of the outcome by Meta-analysis.Results We adopted ultimately 8 studies into our re-search,of which the observation index was effective rate of 5 studies,while for remaining 3 studies the observation targets were PD (pocket depth),AL(attachment loss)and BI(bleeding index).There were no statistically significant differences in all the results of meta-analysis,except PD before and 3 months after SRP by Nd:YAG laser assisting initial therapy of periodontal diseases,accordingly no significant publication bias was found.Conclusions There was significant improvement in clinical efficiency on PD before and 3 months after SRP(scaling and root planning,SRP)by Nd:YAG laser assisting initial therapy of periodontal diseases,while the rest out-comes should be researched further patiently.%目的：采用 Meta 分析系统评价掺钕钇铝石榴石晶体激光（Neodymium －doped yttrium aluminium garnet，Nd：YAG）辅助牙周基础治疗的疗效。方法通过电子检索和手动检索中文发表的期刊文献、会议论文和学位论文，收集 Nd：YAG 激光辅助牙周基础治疗和单纯牙周基础治疗比较的临床研究资料。根据制定的纳入标准和排除标准，对纳入的文献研究进行质量评价、数据提取，并进行异质性检验和 Meta 分析，对得出的结果进行发表偏倚检验。结果共有8篇文献研究纳入本项 Meta分析，其中5篇文献研究的观察指标为有效率，其余3篇的观察指标是牙周探诊深度、附着丧失和出血指数。结果显示 Nd：YAG 激光辅助牙周基础治疗在治疗后3个月时对牙周袋深度的改善效果明显，其余统计结果未见显著性差异，所有统计结果也未见明显的发表偏倚。结论Nd：YAG 激光辅助牙周基础治疗在治疗后3个月时对牙周袋深度的改善效果明显，其余结果有待进一步研究论证。
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