首页> 中文期刊> 《TMR现代中药》 >Effects and safety of Ding Kun Dan on IVF/ICSI-ET outcomes in patients with predicted poor ovarian response:A multicenter randomized clinical trial

Effects and safety of Ding Kun Dan on IVF/ICSI-ET outcomes in patients with predicted poor ovarian response:A multicenter randomized clinical trial

         

摘要

Objective:To evaluate whether Ding Kun Dan(DKD)can improve the vitro fertilization/intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET)outcomes in patients with predicted poor ovarian response(POR)safely and effectively.Methods:Prospective,multicenter,randomized controlled trial;A total of 278 POR patients were randomized in DKD group or immediate treatment group.Both groups received IVF or ICSI as a standard treatment while in the DKD group,DKD was administrated for 3 months before the IVF/ICSI cycle.The primary outcome was the ongoing pregnancy rate.The secondary outcomes include clinical pregnancy rate,biochemical pregnancy rate,total gonadotropin(Gn)dosage and duration,estradiol(E2)and progesterone(P)levels on human chorionic gonadotropin(hCG)trigger day,cycle cancellation rate,number of oocytes retrieved,high-quality embryo rate and any adverse events.Results:Compared to the immediate IVF treatment group,oral administration of DKD for 3 months before IVF led to a significant increase in ongoing pregnancy rate(30.0%v.s.17.6%,P0.05).No serious adverse events occurred during the intervention period in either group.Conclusion:DKD is a safe and effective intervention to improve the IVF/ICSI-ET outcomes in patients with POR.

著录项

  • 来源
    《TMR现代中药》 |2021年第3期|P.1-10|共10页
  • 作者单位

    Reproductive Center First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300112 China;

    Center of Reproductive Medicine The Second Hospital of Hebei Medical University Shijiazhuang 050000 China;

    Reproductive Center First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300112 China;

    Reproductive Center First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300112 China;

    Reproductive Center First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300112 China;

    Center of Reproductive Medicine General Hospital of Tianjin Medical University Tianjin 300052 China;

    Center of Reproductive Medicine Tianjin First Center Hospital Tianjin 300190 China;

    Reproductive Center First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300112 China;

    Reproductive Center First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300112 China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 妇产科学;
  • 关键词

    Traditional Chinese medicine; Ding Kun Dan; Poor ovarian response; In vitro fertilization; Intracytoplasmic sperm injection;

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