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首页> 中文期刊> 《中医科学杂志(英文)》 >Exploration of the potential mechanism of Danggui Shaoyao powder in the treatment of endometriosis based on bioinformatics

Exploration of the potential mechanism of Danggui Shaoyao powder in the treatment of endometriosis based on bioinformatics

         
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摘要

Background:Endometriosis is a hormone-and organ-dependent disease with unclear pathogenesis.Danggui Shaoyao powder(DSP)has been used for the treatment of endometriosis for many years and has been proven to be effective,but its underlying molecular mechanisms remain unclear.In this study,we explored the molecular targets and pathways of DSP in the treatment of endometriosis mainly from the perspective of network pharmacology,and provided some novel ideas for managing this disease.Methods:In the present study,we focused on the underlying mechanisms between DPS and endometriosis,via oral bioavailability screening,drug similarity assessment,target identification,network analysis,drug relocation,and molecular docking using network pharmacology.Results:By bioinformatics,54 active components of DSP were predicted from the 534 components provided by the TCMSP database.We then found 85 validated targets and 6059 predicted targets for herbal components,and 2241 targets for endometriosis.After mapping,there were 255 targets in common.After that,network analysis was performed to screen key networks and core targets.Ninetynine indirect targets were collected from 14 direct ones.GO and KEGG analyses identified 63 enriched functions and 10 pathways(P<.01).According to the disease target,dipyridamole could undergo drug repositioning for endometriosis(score?1).The mechanism of action of dipyridamole on endometriosis was compared with that of DSP.Finally,eight targets,namely,AR,ESR1,HMGCR,NOS2,NR3C1,PPARG,PTGES,and PTGS2,were validated by molecular docking,suggesting that the probable molecular mechanisms by which DSP treats endometriosis are through seven validated pathways:hsa05200,hsa04915,hsa01100,hsa00900,hsa04920,hsa01130,and hsa00590.Conclusion:In this study,we uncovered the mechanism by which DSP can treat endometriosis using a drugecomponentetarget interaction network.This approach can provide some novel ideas for the development of Chinese medicine and the clinical management of endometriosis.

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  • 来源
    《中医科学杂志(英文)》 |2019年第4期|P.355-364|共10页
  • 作者

    Xiuping Zhang; Lulu Zhang; Qi Wang; Xinhui Sun; Yang Dong; Yu Xing; Xiaona Ma;

  • 作者单位

    School of Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing 102488 China;

    School of Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing 102488 China;

    School of Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing 102488 China;

    Department of Gynecology Beijing University of Chinese Medicine Third Affiliated Hospital Beijing 100029 China;

    School of Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing 102488 China;

    Harvard Medical School Brigham and Women’s Hospital 02115 Boston MA USA;

    Department of Gynecology Beijing University of Chinese Medicine Third Affiliated Hospital Beijing 100029 China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 计算技术、计算机技术;
  • 关键词

    Danggui shaoyao powder; Endometriosis; Network pharmacology; Molecular docking; Mechanism;

    机译：Danggui Shaoyao粉;子宫内膜异位症;网络药理学;分子对接;机制;
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