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首页> 中文期刊> 《传统医学研究（英文版）》 >Pharmacological intervention of traditional Chinese medicine for the quality of life in patients with colorectal cancer:a systematic review and meta-analysis

Pharmacological intervention of traditional Chinese medicine for the quality of life in patients with colorectal cancer:a systematic review and meta-analysis

         
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摘要

Objective: The objective of this study is to evaluate the impact of various traditional Chinese medicine (TCM) approaches on the quality of life in patients with colorectal cancer. Methods:In this study, we systematically performed the screening of randomized controlled trials from Cochrane Library, Pubmed, Embase, Medline, and Web of Science. The data were extracted by two reviewers independently, and then risk assessment was performed. All the analyses were conducted using Review Manager 5.3. Results:A total of 18 eligible studies containing 1312 patients were included. Experimental group were treated with TCM combined with Western medicine or TCM alone (N = 688) and control group were treated with Western medicine treatment alone (N = 624). The results showed that the recent clinical efficiency between the two groups was not statistically significant (P=0.06). KPS scores of the experimental group were higher than those in the control group [P < 0.001, WMD = 9.60, 95％CI = (5.62, 13.57)]. The toxicity comparison showed that the occurrence of toxicities, such as leucopenia, thrombocytopenia, nausea and vomiting, diarrhea, and neurotoxicity in the experimental group was lower than that in the control group [P<0.001, OR=0.31, 95％CI=(0.19, 0.50)], [P=0.003, OR=0.49, 95％CI=(0.31, 0.78)], [P<0.001, OR=0.30, 95％CI=(0.16, 0.54)], [P<0.001, OR=0.40, 95％CI = (0.27, 0.58)], and [P < 0.001, OR = 0.43, 95％CI = (0.30, 0.61)]. The immunological test comparison demonstrated that the immunological parameters (CD3, CD4, and CD4/CD8) showed higher values in the experimental group than those in the control group [P<0.001, MD=5.55, 95％CI=(4.83, 6.28)], [P<0.0001, MD=6.75, 95％CI=(5.25, 8.26)], and [P= 0.001, MD = 0.26, 95％CI = (0.10, 0.41)]. Conclusions: TCM did not show significant recent clinical efficiency. However, treatment with TCM showed increase in KPS scores in patients with colorectal cancer, alleviation of toxicity associated with chemotherapy, regulation of autoimmunity, and improvement in the quality of life of patients.%目的:评价不同中医药方法对结直肠癌患者生活质量的影响.方法:从Cochrane,Pubmed,Embase,Medline和Web of Science数据库中筛选随机对照试验来进行系统研究,并由两名评审员独立提取数据,使用软件Review Manager 5.3进行数据处理.结果:共有18个合格研究,1312名患者被纳入.实验组采用中医药结合西医治疗,或单纯中医药治疗;对照组采用西医治疗.结果显示:(1)实验组与对照组近期有效率比较,差异不具有统计学意义[P=0.06,0R=1.38,95％CI=(0.98,1.95)].(2)实验组的KPS评分高于对照组[P<0.001,WMD=9.60,95％CI=(5.62,13.57)].(3)实验组与对照组毒副反应比较:实验组白细胞下降,血小板减少,恶心呕吐,腹泻,神经毒性不良反应的发生率均低于对照组[P<0.001,OR=0.31,95％CI=(0.19,0.50)],[P=0.003,OR=0.49,95％CI=(0.31,0.78)],[P<0.001,OR=0.30,95％CI=(0.16,0.54)],[P<0.001,OR=0.40,95％CI=(0.27,0.58)]和[P<0.001,OR=0.43,95％CI=(0.30,0.61)].(4)实验组与对照组免疫学检测比较:实验组的CD3,CD4,和CD4/CD8的均值均高于对照组[P<0.001,MD=5.55,95％CI=(4.83,6.28)],[P<0.001,MD=6.75,95％CI=(5.25,8.26)],[P=0.001,MD=0.26,95％CI=(0.10,0.41)].结论:中医药对结直肠癌患者的近期临床有效率作用不显著,但可提高患者的KPS评分,缓解化疗的毒副作用,调节自身免疫,改善患者的生活质量.

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  • 来源
    《传统医学研究（英文版）》 |2018年第2期|95-105|共11页
  • 作者

    Wen-Qi Huang; Zhu Yang; Dong-Xin Tang; Feng-Xi Long; Li Luo; Bing Yang; Juan Li; Jie Chen;

  • 作者单位

    Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, China;

    Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, China;

    The First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, China;

    Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, China;

    The First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, China;

    Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, China;

    Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, China;

    Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, China;

  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    结直肠癌; 中医药; 生活质量; Meta分析;

    机译：结直肠癌;中医药;生活质量;Meta分析;
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