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首页> 外文期刊>传统医学研究（英文版） >Efficacy and safety of traditional Chinese medicine kidney-nourishing formula for Alzheimer's disease in comparison with donepezil: a systematic review and meta-analysis
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Efficacy and safety of traditional Chinese medicine kidney-nourishing formula for Alzheimer's disease in comparison with donepezil: a systematic review and meta-analysis

机译：中药补肾配方与多奈哌齐的疗效和安全性：系统评价和荟萃分析

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摘要

Objective:Finding an effective therapy against Alzheimer’s disease(AD)has been associate increasingly pressing issue and traditional Chinese medicine(TCM)is widespread in the prevention and treatment of AD in China.The aim of this study was to judge the efficaciousness and safety of TCM kidney-nourishing(the changes of pathological state of kidney deficiency by means of TCM treatment and so on)formula(TKNF)for AD in comparison with donepezil.Methods:The retrieval period of seven databases was from the establishment of each database to April 2019.Two authors independently identified randomized controlled trials(RCTs),fetched data and assessed bias risk.Comprehensive analysis process was conducted with review manager for eligible and appropriate RCTs.Results:A complete of 981 AD patients from 13 studies were enclosed.Meta-analysis of RCTs showed that there was no significant difference in the improvement of Alzheimer's disease assessment scale-cognitive subscale score between 2 groups in short term,but the effect of long-term treatment may exceed donepezil;there was a significant difference in the improvement of activities of daily living score between 2 groups;there was a significant difference in TCM curative efficacy between 2 groups with long-term treatment.There was no significant difference in the incidence of adverse events between 2 groups.The quality of the evidence was high or moderate.Conclusion:Compared with donepezil,TKNF was an effective drug for AD patients and the clinical application of TKNF was safe.TKNF's long-term benefits need more evidence to verify.

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  • 来源
    《传统医学研究（英文版）》 |2020年第5期|337-354|共18页
  • 作者

    Fei-Zhou Li; Yi-Ni Zhang; Tong Zhang; Ling Liu; Ping Wang;

  • 作者单位

    Clinical College of Chinese Medicine Hubei University of Chinese Medicine Wuhan China;

    Clinical College of Chinese Medicine Hubei University of Chinese Medicine Wuhan China;

    Clinical College of Chinese Medicine Hubei University of Chinese Medicine Wuhan China;

    Encephalopathy Department Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan China;

    Institute of Gerontology Hubei University of Chinese Medicine Wuhan China;

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